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Distinguished Professor of The City University of New York
Biomedical Engineering,Mechanical Engineering
| Office Location: |
Steinman Hall T - 404B |
| Phone: |
(212)650-5202 |
| Fax: |
(212)650-8013 |
| E-mail: |
weinbaum@ccny.cuny.edu |
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Education:
B.A.E., 1959, Rensselaer Polytechnic Institute
M.S. Applied Physics, 1960, Harvard University
Ph.D. Engineering, 1963, Harvard University
Gordon McKay Prize Fellow, Harvard University (1959-1961)
NSF Fellow, Harvard University (1961-1963)
Senior Fellow Scientific Research Council of Great Britain (1974)
NSF "Special Creativity" Award (1985)
Public Service Award of New York (1988)
Research Award of the European Society of Biomechanics (1994)
H.R.Lissner Award and Melville Medal of the ASME (1994)
Best Paper Award Bioengineering Division ASME (1995)
Melville Medal of the ASME (1996)
Whitaker Distinguished Lecture BMES (1997)
Richard Skalak Memorial Lecture UCSD (1999)
Classic Paper Award Heat Transfer Division ASME (2000)
Suhren Lecture Tulane University (2002)
Guggenheim Fellow in Molecular and Cellular Biology (2002)
Huck Lecture Pennsylvania State University (2004)
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Areas of Expertise:
fluid dynamic and transport aspects of arterial disease bioheat transfer
cellular mechanisms for mechanotransduction
bone fluid flow
microcirculatory exchange
transport in kidney proximal tubule
basic fluid mechanics
porous media flows
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Current Research Interests:
Professor Weinbaum has published more than 185 full length papers plus numerous shorter communications and conference papers. His research has involved important collaborations with other investigators and institutions. His joint studies with the UC San Diego have investigated the cellular origins of the permeability of arterial endothelium to low density lipoproteins, transport models for the arterial intima and the formation of subendothelial liposomes. His studies in bioheat transfer have examined the development of a fundamental bioheat equation to describe microvascular blood-tissue heat transfer (Weinbaum-Jiji equation) and the application of bioheat models to describe heat transfer in muscle tissue, limbs, rat tail and finger. His joint studies with the UC Davis have attempted to elucidate the structural pathways through the interendothelial cleft that determine capillary permeability and osmotic forces. His joint studies with S. C. Cowin have explored the cellular transduction mechanism by which bone cells detect mechanically induced strains and communicate these strains to the bone forming cells. His studies with Weill-Cornell Medical School have led to a new hypothesis for the mechanosensory mechanism that leads to the glomerulotubular balance in the kidney. He has also examined a wide variety of basic fluid mechanics problems that have arisen in biologically motivated applications. More than 30 of these papers have been published in the Journal of Fluid Mechanics.
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Current Research Associates:
B.M.Liaw, Department of Mechanical Engineering, The City College of New York
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Current Professional Affiliations:
Elected member National Academy of Engineering
Elected member National Academy of Sciences
Elected member Institute of Medicine of the National Academies
Fellow: ASME, AIMBE, APS.
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Selected Recent Publications:
Han, Y., Cowin, S., Schaffler, M., and Weinbaum, S.,
“Mechanotransduction and Strain Amplification in Osteocyte Cell
Processes”, Proc. Nat’l. Acad. Sci. USA, 101, 16689-16994,(2004)
Thi, MM, Tarbell, J., Weinbaum, S., and Spray D., “The Role of the
Glycoalyx in Reorganizationof the Actin Cytoskeleton under Fluid Shear
Stress: A ‘Bumper Car’ Model”, Proc. Nat’l. Acad. Sci. USA, 101,
16483-16488, (2004)
Du, Z, Duan, Y., Yan, Q-S, Weinstein, A. M., Weinbaum, S., Wang, T.,
“Mechansensory Function of Microville of the Kidney Proximal Tubule”,
Proc. Nat. Acad. Sci. USA, 101,13068-13073, (2004)
Wu, Q., Andreopoulos, Y. and Weinbaum, S., “From Red Cells to
Snowboarding to a NewConcept for Train Track”, Physical Review Lett.,
93, 194501 (2004)
Adamson, R. H., Lenz, J. F., Zhang, X., Adamson, G. N., Weinbaum, S.
and Curry, F.E.,“Oncotic Pressures Opposing Filtration Across
Non-fenestrated Rat Microvessels”, J. Physiology, 557.3 889-907,
(2004)
You, L., Weinbaum, S., Cowin, S.C., and Schaffler, M.B.,
"Ultrastructure of the Osteocyte Process", Anatomical Rec. 278A,
505-513, (2004)
Weinbaum, S., Zhang, X., Han, Y., Vink, S., Cowin, S.C.,
“Mechanotransduction and FlowAcross the Endothelial Glycocalyx”, Proc.
Nat. Acad. Sci. USA, 100, 7988-7995, (2003)
Liu, W., Xu, S., Woda, C., Kim, P., Weinbaum, S., Satlin, L., “Effect
of Flow and Stretch on the[Ca2+]i Response of Principal and
Intercalated Cells in Cortical Collecting Duct”, Am. J. Physiol. 285,
F998-F1012, (2003)
Guo, P. Weinstein, A., Weinbaum, S., “A Dual Pathway Ultrastructural
Model for the Tight Junction of a Rat Proximal Tubule Epithelium”, Am.
J. Physiol. 285, F241-F257, (2003)
He, Q., Zhu, L., Weinbaum, S., “Effect of Blood Flow on Thermal
Equilibration and Venous Rewarming”, Annals of Biomed. Engr. 31,
659-666, (2003)
Thi, M., Kojima, T., Cowin, S.C., Weinbaum, S., Spray, D., “ Fluid
Shear Stress RemodelsExpression and Function of Junctional Proteins in
Cultured Bone Cells”, Am. J. Physiol., Cell Physiology 284, C389-C403,
(2003)
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