B.S., 1974, Tufts University;
Ph.D., 1981, University of Virginia.

• cardiac cellular electrophysiology
• cardiac ion channels: biophysics, regulation, pharmacology, development
• properties of unitary L-type Ca channels
• Na and Ca channel gating currents
• local Ca signaling in normal adult, aging, and failing hearts
• cardiac-directed embryonic stem cells

• Josephson, I.; Sperelakis, N. On the ionic mechanism underlying the adrenergic-cholinergic antagonism in ventricular muscle. J. Gen. Physiol. 79: 69-86; 1982.
• Josephson, I. R.; Sanchez-Chapula, J.; Brown, A.M. Early outward current in single rat ventricular cells. Circ. Res. 54: 157-162; 1984.
• Josephson, I.R. Initiation and propagation of the cardiac action potential, in: Essentials of Basic Science: Physiology 2nd Edition. Eds. N. Sperelakis and R.Banks. Little, Brown, 1996.
• Josephson, I.R., Varadi, G. Beta subunit increases calcium currents and gating charge movements of human L-type Ca channels. Biophysical Journal 70:1285-1293, 1996.
• Guia, A. Stern, M., Lakatta, E., and I.R. Josephson. 2001. Ion concentration-dependence of rat cardiac unitary L-type calcium channel conductance. Biophys. J. 80: 2742-2750.
• Josephson, I.R. and Guia, A. Measuring single L-type channel currents in isolated heart cells. ISHR Online HELP Files (www.ishrworld.org ) 2001.
• Song. L-S, Guia, A., Muth, J., Wang, S-Q, Xiao, R-P, Josephson, I.R., Schwartz, A., Lakatta, E.G., Cheng, H. Ca signaling in hypertrophic transgenic cardiac myocytes overexpressing the a1 subunit of l-type Ca channel. Circ. Res. 90:174-181, 2002.
• Josephson, I.R., Guia, A., Stern, M. and Lakatta, E. Alterations in properties of single cardiac L-type Ca channel currents in aging rat heart. J Mol Cell Cardiol. 34(3):297-308, 2002.
• Josephson, I.R., Guia, A., Lakatta, E.G., and M. D. Stern. 2002a. Modulation of the gating of unitary cardiac L-type Ca channels by conditioning voltage and divalent Ions. Biophys. J. 83; 2575-2586.
• Josephson, I.R., Guia, A., Lakatta, E.G., and M. D. Stern. 2002b. Modulation of the conductance of unitary cardiac L-type Ca channels by conditioning voltage and divalent Ions. Biophys. J. 83; 2587-2594.
• Josephson, I.R., Lederer, W.J., Hartmann, H.A. Letter Regarding the Article by Darbar, et al., “Unmasking of Brugada Syndrome by Lithium”. Circulation; Mar 14; 113; 2006.

Last Updated: 2/22/09