J. Foxe's General Info.

Degree/Date: B.A., 1987
Institution: University College Dublin
Specialization: English and History

Degree/Date: B.Sc., 1989
Institution: Iona College
Specialization: Experimental Psychology

Degree/Date: M.Sc., 1996
Institution: Albert Einstein College of Medicine
Specialization: Neurophysiology

Degree/Date: Ph.D., 1999
Institution: Albert Einstein College of Medicine
Specialization: Neuroscience

Research Interests/Activities: The goal of my research is to investigate and characterize the neural mechanisms of cognitive operations that lead to human perception and action. To achieve a full understanding of such cognitive operations, our investigations must encompass knowledge from the macroscopic brain structural level to the microscopic level of single neurons and receptor channels. We must also embrace issues of brain connectivity, functional specificity within brain modules and the spatiotemporal dynamics of activations across the brain network. Thus, our approach is to 1) identify underlying brain regions, neuron populations and connections (i.e., the "active circuits"), 2) to identify physiological and, if possible, pharmacological processes within active circuits and 3) to define temporal activity patterns within each active brain module and across the modules comprising a given active circuit.

Professional Activities: Director, Cognitive Neuroscience Ph.D. Subprogram, City University of New York; Director, Cognitive Neuroscience Laboratory, Nathan Kline Institute for Psychiatric Research.

Current Projects: P.M. Dockree, S.P. Kelly, J.J. Foxe, R.B. Reilly, I.H. Robertson, “Optimal sustained attention is linked to the spectral content of background EEG activity: Greater ongoing tonic alpha (~10Hz) power supports successful phasic goal activationâ€, European Journal of Neuroscience, In Press, 2007. D. Senkowski, D. Saint-Amour, S.P. Kelly, J.J. Foxe, “Multisensory processing of naturalistic objects in motion: A high-density electrical mapping and source estimation study â€, NeuroImage, In Press, 2007 Gomez-Ramirez M, Higgins BA, Rycroft JA, Owen GN, Mahoney J, Shpaner M, Foxe JJ. The deployment of Intersensory Selective Attention: A high-density electrical mapping study of the effects of theanine. Clinical Neuropharmacology. In press 2007.

Recent Publications:

Saint-Amour, D., De Sanctis, P., Molholm, S., Ritter, W., and Foxe, J.J. Seeing Voices: High-density electrical mapping and source-analysis of the multisensory mismatch negativity evoked during the McGurk illusion. Neuropsychologia, 2007, 45: 587-597.

Butler, P.D., Martinez, A., Foxe, J.J., Kim, D., Silipo, G., Mahoney, J., Shpaner, M., Jalbrikowski, M., Javitt, D.C. Subcortical Visual Dysfunction In Schizophrenia Drives Secondary Cortical Impairments. Brain, 2007, 130: 417-430.

Gomez-Ramirez, M., Higgins, B.A., Rycroft, J.A., Owen, G.N., Mahoney, J., Shpaner, M. and Foxe, J.J. The deployment of Intersensory Selective Attention: A high-density electrical mapping study of the effects of theanine. Clinical Neuropharmacology, 2007, 30: 25-38.

Alexopoulos, G.S., Murphy, C., Gunning-Dixon, F.M., Kalayam, B., Katz, R., Kanellopoulos, D., Etwaroo, G.R., Klimstra, S. and Foxe, J.J. Event-related potentials in an affective Go/Nogo task and remission of geriatric depression. Neuroreport, 2007, 18: 217-221.

Senkowski, D., Gomez-Ramirez, M., Lakatos, P., Wylie, G.R., Molholm, S., Schroeder, C.E. and Foxe, J.J. Multisensory processing and oscillatory activity: analyzing non-linear electrophysiological measures in humans and simians. Experimental Brain Research, 2007, 177: 184-195.

Dockree, P.M., Kelly, S.P., Foxe, J.J., Reilly, R.B., Robertson, I.H. Optimal sustained attention is regulated by the spectral content of background EEG activity: Greater ongoing tonic alpha (~10Hz) power supports successful phasic goal activation. European Journal of Neuroscience, 2007, 25: 900-907.

 Leitman, D.L., Hoptman, M., Foxe, J.J., Wylie, G.R., Nierenberg, J., Pasternak, R., Jalbrzikowski, M., Javitt, D.C. The neural substrates of impaired prosodic detection in schizophrenia and its sensorial antecedents. American Journal of Psychiatry, 2007, 164: 474-482.

Ross, L.A., Saint-Amour, D., Leavitt, V., Javitt, D.C., and Foxe, J.J. Do you see what I’m saying? Optimal Visual Enhancement of Speech Comprehension in Noisy Environments. Cerebral Cortex, 2007, 17: 1147-1153.

O’Connell, R., Dockree, P.M., Bellgrove, M.A., Hester, R., Garavan, H., Robertson, I.H. and Foxe, J.J. The role of Cingulate Cortex in the detection of errors with and without awareness: A high-density electrical mapping study. European Journal of Neuroscience, 2007, 25: 2571-2579.

Senkowski, D. Saint-Amour, D., Kelly, S.P and Foxe, J.J. Multisensory processing of naturalistic objects in motion: A high-density electrical mapping and source estimation study. Neuroimage, 2007, 36: 877-888.

Molholm, S., Martinez, A., Shpaner, M., Foxe, J.J. Object-Based Attention is Multisensory: Co-activation of an Object’s Representations in Ignored Sensory Modalities. European Journal of Neuroscience, 2007, 26: 499-509.

Martinez, A., Ramanathan, D.S., Foxe, J.J., Javitt, D.C., Hillyard, S.A. The role of spatial attention in the selection of real and illusory objects. Journal of Neuroscience, 2007, 27: 7963-7973.

 Leavitt, V.M., Molholm, S., Ritter, W., Shpaner, M., and Foxe, J.J. Auditory processing in schizophrenia during the middle latency period (10-50 milliseconds): High-density electrical mapping and source-analysis reveal subcortical antecedents to early cortical deficits. Journal of Psychiatry & Neuroscience, 2007, 32: 339-353.

Hester , R., Barre, N., Mattingly, J.B., Foxe, J.J. and Garavan, H. Avoiding another mistake: Error and post-error neural activity associated with adaptive post-error behaviour change. Cognitive, Affective and Behavioural Neuroscience, 2007, 7: 317-326.

Ross, L.A., Saint-Amour, D., Leavitt, V.M., Molholm, S., Javitt, D.C., and Foxe, J.J. Impaired Multisensory Processing in Schizophrenia: Deficits in Visual Enhancement of Speech Comprehension Under Noisy Environmental Conditions. Schizophrenia Research, 2007, 97: 173-183.

Lalor, E.C., Kelly, S.P., Pearlmutter, B., Reilly, R.B., and Foxe, J.J. Isolating endogenous visuo-spatial attentional effects using the novel Visual Evoked Spread Spectrum Analysis (VESPA) technique. European Journal of Neuroscience, 2007, 26: 3536-3542.

Lalor, E.C., Yeap, S., Reilly, R.B., Pearlmutter, B.A., and Foxe J.J. Dissecting the cellular contributions to early visual sensory processing deficits in schizophrenia using the VESPA evoked response. Schizophrenia Research, 2008, 98: 256-264.

Donohoe, G., Morris, D.W., De Sanctis, P., Magno, E., Montesi, J.L., Garavan, H.P., Robertson, I.H., Javitt, D.C., Gill, M., Corvin, A.P. and Foxe, J.J. Early Visual Processing Deficits in Dysbindin-Associated Schizophrenia. Biological Psychiatry, 2008, 63: 484-489.

Wylie, G.R., Foxe, J.J., Taylor, T.L. Forgetting as an Active Process: An fMRI Investigation of Item-Method-Directed Forgetting. Cerebral Cortex, 2008, 18: 670-682. De Sanctis, P., Ritter, W., Molholm, S., Kelly, S.P., and Foxe, J.J. Auditory Scene Analysis: The interaction of stimulation rate and frequency separation on preattentive grouping. European Journal of Neuroscience, 2008, 27: 1271-1276.

Sehatpour, P., Molholm, S., Schwartz, T.H., Mahoney, J.R., Mehta, A.D., Javitt, D.C., Stanton, P.K., and Foxe, J.J. Long-range oscillatory coherence across a frontal-occipital-hippocampal brain network during visual object processing: A human intracranial study. Proceedings of the National Academy of Sciences USA, 2008, 105: 4399-4404.

Moran, R.J., Reilly, R.B., Molholm, S., and Foxe, J.J. Changes in Effective Connectivity of Human Superior Parietal Lobule under Multisensory and Unisensory Stimulation. European Journal of Neuroscience, 2008; 27: 2303–2312.

De Sanctis, P., Katz, R., Alexopoulos, G.S., Wylie, G.R. and Foxe, J.J. Enhancement and bilateralization of early sensory processing in the ventral visual stream may be a feature of normal aging: A high-density electrical mapping study. Neurobiology of Aging, in press.

McCourt, M.E., Shpaner, M., Javitt, D.C., and Foxe, J.J. Hemispheric asymmetry and callosal integration of visuospatial attention in schizophrenia: A tachistoscopic line bisection study. Schizophrenia Research, in press.

Magno, E., Yeap, S., Thakore, J.H., Garavan, H., De Sanctis, P., Javitt, D.C., and Foxe, J.J. Are Auditory-Evoked Frequency and Duration Mismatch Negativity (MMN) Deficits Endophenotypic for Schizophrenia? High-Density Electrical Mapping in Clinically Unaffected First-Degree Relatives, First-Episode Psychosis and Chronic Schizophrenia. Biological Psychiatry, in press.

Simões-Franklin, C., Hester, R., Shpaner, M., Foxe, J.J., and Garavan, H. Executive Function and Error Detection: Dissociation between Proactive and Reactive Cingulate and Ventral Striatum Activity. Journal of Neuroscience, in press.

Wylie, G.R., Murray, M.M., Javitt, D.C. and Foxe, J.J. Distinct neurophysiological mechanisms mediate mixing costs and switch costs. Journal of Cognitive Neuroscience, in press.

Kelly, S.P., Gomez-Ramirez, M., Montesi, J.L., and Foxe, J.J. The effects of L-theanine and caffeine on oscillatory alpha-band activity and attention task performance. Journal of Nutrition, in press.

Yeap, S., Kelly, S.P., Sehatpour, P., Magno, E., Garavan, H., Thakore, J.H., and Foxe, J.J. Visual sensory processing deficits in Schizophrenia and their relationship to disease state. European Archives of Psychiatry and Clinical Neuroscience, in press.

Kelly, S.P., Gomez-Ramirez, M., & Foxe, J.J. Spatial attention modulates initial afferent activity in human primary visual cortex. Cerebral Cortex, in press.

O’Connell, R.G., Dockree, P.M., Bellgrove, M.A., Turin, A., Ward, S., Foxe, J.J., & Robertson, I.H. Two types of action error: electrophysiological evidence for separable inhibitory and sustained attention neural mechanisms producing error on Go/No-go tasks. Journal of Cognitive Neuroscience, in press.

O’Connell, R., Bellgrove, M.A., Dockree, P.M., Lau, A., Hester, R., Garavan, H., Fitzgerald, M., Foxe, J.J. , and Robertson, I.H. Efficiency of error detection networks in adult ADHD – an electrophysiological analysis. Brain, in press.

Dale, C.L., Simpson, G.V., Foxe, J.J., Luks, T.L., Worden, M.S. ERP correlates of anticipatory attention: spatial and non-spatial specificity and relation to subsequent selective attention. Experimental Brain Research, in press.

Foxe, J.J., Strugstad, E.C., Sehatpour, P., Javitt, D.C., Pasieka, W., Schroeder, C.E., McCourt, M.E. Parvocellular and Magnocellular contributions to the initial generators of the visual evoked potential: High-density electrical mapping of the “C1” component. Brain Topography, in press.

Senkowski, D., Saint-Amour, D., Gruber, T., and Foxe, J.J. Look who’s talking: The deployment of visuo-spatial attention during multisensory speech processing under noisy environmental conditions, Neuroimage, in press.

Barnett, K.J., Foxe, J.J., Molholm, S., Kelly, S.P., Shalgi, S., Mitchell, K.J., and Newell, F.N. Differences in early sensory-perceptual processing in synesthesia: a visual evoked potentials study. Neuroimage, in press.

Yeap, S., Kelly, S.P., Thakore, J.H., and Foxe, J.J. Visual Sensory Processing Deficits in First-Episode Patients with Schizophrenia. Schizophrenia Research, in press.

Fassbender, C., Hester, R., Foxe, J.J., Foxe, D.M., and Garavan, H. Prefrontal and midline interactions mediating behavioural control. European Journal of Neuroscience, in press.

Butler, P.D., Martinez, A., Foxe, J.J., Kim, D., Silipo, G., Mahoney, J., Shpaner, M., Jalbrikowski, M., Javitt, D.C. Reply: A few remarks on assessing magnocellular sensitivity in patients with schizophrenia. Brain, 2007, 130(11): e84.

Lalor, E.C., Pearlmutter, B.A., and Foxe, J.J. Reverse Correlation and the VESPA Method. In: T.C. Handy (Ed). Advances in ERP, EEG and MEG Analysis, MIT Press, to appear in 2008.

Senkowski, D., Schneider, T.R., Foxe, J.J. and Engel, A.K. Cross-modal binding by coherence of neural signals: new vistas on multisensory processing. Trends in Neuroscience, in press.

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